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Gastric Neuroendocrine Neoplasms Toshiaki Hirasawa 1 , Hiroshi Kawachi 2 , Takashi Ichimura 1 , Koshi Kumagai 1 , Sho Shiroma 1 , Ken Namikawa 1 , Akira Yamasaki 1 , Kaoru Nakano 1 , Shoichi Yoshimizu 1 , Kazuhisa Yamaguchi 1 , Tomoki Shimizu 1 , Yusuke Horiuchi 1 , Akiyoshi Ishiyama 1 , Toshiyuki Yoshio 1 , Yorimasa Yamamoto 1 , Tomohiro Tsuchida 1 , Junko Fujisaki 1 1Gastroenterology Center, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo 2Department of Pathology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo Keyword: 胃neuroendocrine tumor , 胃neuroendocrine carcinoma , 胃カルチノイド , Rindi分類 , A型胃炎 pp.63-73
Published Date 2017/1/25
DOI https://doi.org/10.11477/mf.1403200814
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 The classification and nomenclature of digestive neuroendocrine tumors have changed over the past 100 years. It is now accepted in WHO(the World Health Organization)2010 classification.

 In the WHO classification, neoplasms exhibiting phenotypes of the endocrine system are called NENs(neuroendocrine neoplasms). NENs are classified as well-differentiated neuroendocrine tumors(NETs)and poorly differentiated NECs(neuroendocrine carcinomas). NETs are further divided as NETs G1 and NETs G2 according to a grading scheme based on the mitotic count or Ki67 index.

 Rindi et al. classified gastric NENs into three subtypes. Types I and II are associated with hypergastrinemia, while type III consists of sporadic tumors without hypergastrinemia.

 In patients with type I or II NENs, endoscopic surveillance or endoscopic resection is recommended because of low-grade malignancy. In patients with type III NENs, gastrectomy with lymph node dissection is recommended because of high-grade malignancy.

 For clarity with regard to the mode of treatment, further studies are needed in the future.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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