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Clinicopathological and Endoscopic Features of Upper Gastrointestinal Lesions in Patients with Amyloidosis Yuji Maehata 1 , Motohiro Esaki 1 , Risa Ichinose 2 , Junji Umeno 1 , Kouichi Asano 1 , Tomohiko Moriyama 1 , Shotaro Nakamura 1 , Minako Hirahashi 2 , Yoshinao Oda 2 , Takanari Kitazono 1 , Takayuki Matsumoto 3 1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 2Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 3Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan Keyword: アミロイドーシス , 胃・十二指腸 , AL型 , AA型 , 経時的推移 pp.301-310
Published Date 2014/3/25
DOI https://doi.org/10.11477/mf.1403114091
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 We investigated endoscopic and pathological features of upper gastrointestinal lesions in 46 patients with amyloidosis. Endoscopic findings of gastric lesions were characterized by submucosal protrusions in the AL-type amyloidosis, and fine granular elevations or multiple nodular protrusions in the AA-type amyloidosis. Duodenal lesions of the AL-type were frequently recognized as multiple submucosal protrusions, in 50% of patients with slight amyloid deposition. Although fine granular elevations were frequently observed in the duodenum of patients with AA-type amyloidosis, endoscopic abnormalities were not observed in some patients with marked amyloid deposition. Endoscopic and histological findings of the duodenal lesions were static in approximately half the patients with amyloidosis. In addition, some duodenal lesions improved with treatment of the primary disease. Our findings suggest that upper gastrointestinal amyloidosis presents various endoscopic findings, regardless of the degree of amyloid deposition, and it progresses slowly.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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